Jan 13, 2016 · The coring and fragmentation of elastomer components used in containment of parenteral drug products continues to be a challenge. Many factors influence these phenomena, so it is critical that a pharmaceutical manufacturer understands how a vial system will be used, for example: what is the recommended needle gauge; is it single- or multi-dose; could spikes, vial adapters or closed system

Mar 3, 2017 · Glass vials (13 mm × 31 mm, 2-mL volume, Schott Pharmaceutical) for each test device were filled with 0.700 mL of deionized water (the volume of a standard single-dose IM IPV vial, including 0.2 mL overfill) using a calibrated micropipette accurate to ±1 μL and sealed with a 13-mm septum (Kimble Chase) and cap (Wheaton).

224 difficult to access. One approach for disinfecting the vial septum in this type 225 of vial shield is to use a right-angle forceps to hold a sterile 70% IPA wipe 226 and direct it down onto the vial septum. It is also acknowledged that such 227 vial shields will disrupt first air contacting the vial septum during certain 228 handling

Description. Pricing. Details. black polypropylene, septum (TEF/red rubber), septum thickness 1.3 mm, 8-425 thread. Expand. Hide. 854987. black polypropylene hole cap, thread for 13-425, PTFE/red rubber septum, for use with 4 mL vials with 13-425 thread, pkg of 100 ea. Expand.

chemical characteristics. The septum is provided with a thin 0.005” PTFE layer laminated to highly pure silicone, and slit through the center for easier needle penetration and to release the vacuum that forms when a large volume of sample is withdrawn from a vial. This septum provides chromatographic characteristics similar to that of a

Nov 10, 2022 · Press [Vial], scroll to Vial size, Press [Mode/Type] to select the vial size from a list, then press [Enter]. Install a new septum into the blue leak test vial. Place the blue leak test vial into priority position 1 (111 vial model) or into tray position 1 (12 vial model). Set the carrier pressure to a low flow

Jan 2, 2006 · Figure 3 - Typical mass chromatogram of volatile residue in hexane caused by PTFE/silicone septa: a) hexane extract of a piece of septum; b) vial septum was punctured once by a syringe to sample 1 μL hexane for GC analysis; c) hexane in the last vial was reanalyzed after 3 days; and d) analyzed immediately after 100 μL hexane was added from one vial to another (the septum was punctured 10

20 mL headspace crimp top vials or screw top vials directly; no effort was made to purge the vials with an inert gas prior to capping. These vial blank samples were used for blank background and potential septa contamination evaluation. Solvent blank samples were prepared by adding 1 mL of solvent blank into a vial and then capping the vial

Analytical Vials. Vials play a significant role in analytical analysis and result reproducibility. Vials must be inert and free of extractables or leachables to prevent affecting results. Using certified, application-specific, contaminant-free vials can significantly reduce risk. We offer a broad spectrum of Supelco ® products including

Jun 8, 2018 · vial septum, they can leave residual drug volume in vials and may not adequately address hazardous drug exposure risk.2-4 Although such manipulations are typically carried out in a primary engineering control (e.g., biologic safety cabinet), repeated vial access through these adapters may introduce environmental contaminants such as

Apr 18, 2019 · Syringe plunger septum!!! We recommended that the client audit their manufacturing process with respect to light grey rubber sources (e.g. gaskets, o-rings, septa) They could also approach their suppliers as the particle may have an upstream source The septum is a black rubber, so it is ruled out as a potential source of the particle

The test results confirm the vials, cap and septa have been properly manufactured, handled and packaged, and are free from any potential contaminants which could result in chromatographic ghost peaks. Compatible with all autosamplers Combination packs for easy ordering Complete selection of vial sizes and materials

854985. black polypropylene hole cap, thread for 8-425, PTFE/silicone (red PTFE/creme silicone), septum thickness 1.5 mm, for use with 2 mL vial (standard opening), pkg of 1000 ea. View Pricing.